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	cervical squamous cell carcinoma

Disease ID	1090
Disease	cervical squamous cell carcinoma
Definition	A squamous cell carcinoma arising from the cervical epithelium. It usually evolves from a precancerous cervical lesion. Increased numbers of sexual partners and human papillomavirus (HPV) infection are risk factors for cervical squamous cell carcinoma. The following histologic patterns have been described: conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma. Survival is most closely related to the stage of disease at the time of diagnosis.
Synonym	cancer cell cervix squamous cancer cells cervix squamous cancer of the cervix, squamous cell carcinoma cell cervix squamous carcinoma of the cervix, squamous cell cervical cancer, squamous cell carcinoma cervical epidermoid carcinoma cervical squamous cell carcinoma, nos cervical squamous cell carcinoma, not otherwise specified cervix cancer, squamous cell carcinoma cervix squamous cell carcinoma cervix uteri squamous cell carcinoma epidermoid carcinoma of the cervix squamous cell cancer of the cervix squamous cell carcinoma cervical squamous cell carcinoma cervix squamous cell carcinoma of cervix squamous cell carcinoma of cervix (disorder) squamous cell carcinoma of cervix uteri squamous cell carcinoma of the cervix squamous cell carcinoma of the cervix uteri squamous cell carcinoma of the uterine cervix squamous cell carcinoma of uterine cervix squamous cervical cancer uterine cervical cancer, squamous cell carcinoma uterine cervix cancer, squamous cell carcinoma uterine cervix squamous cell carcinoma
Orphanet	ORPHANET:213767
DOID	DOID:3744
UMLS	C0279671
SNOMED-CT	SNOMEDCT_US_2016_09_01:254886006
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:11) C0007137 \| squamous cell carcinoma \| 64 C0279671 \| squamous cell carcinoma of the cervix \| 48 C0279671 \| squamous cell carcinoma of the uterine cervix \| 20 C0011633 \| dermatomyositis \| 1 C0007134 \| renal cell carcinomas \| 1 C0007134 \| renal cell carcinoma \| 1 C0279671 \| squamous cell cancer of the cervix \| 1 C0002871 \| anemia \| 1 C0206623 \| adenosquamous cell carcinoma \| 1 C0279671 \| squamous cell carcinoma of uterine cervix \| 1 C0007137 \| squamous cell cancer \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:3) 940 \| CD28 \| CIPHER 1493 \| CTLA4 \| CIPHER 29851 \| ICOS \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:96) 37 \| ACADVL \| 1.115 \| DISEASES 51309 \| ARMCX1 \| 3.24 \| DISEASES 51374 \| ATRAID \| 3.431 \| DISEASES 554 \| AVPR2 \| 1.157 \| DISEASES 9531 \| BAG3 \| 1.046 \| DISEASES 578 \| BAK1 \| 1.134 \| DISEASES 8678 \| BECN1 \| 1.545 \| DISEASES 676 \| BRDT \| 1.952 \| DISEASES 682 \| BSG \| 1.157 \| DISEASES 900 \| CCNG1 \| 1.509 \| DISEASES 960 \| CD44 \| 1.005 \| DISEASES 1029 \| CDKN2A \| 3.355 \| DISEASES 1164 \| CKS2 \| 1.838 \| DISEASES 54544 \| CRCT1 \| 3.105 \| DISEASES 1499 \| CTNNB1 \| 2.532 \| DISEASES 9547 \| CXCL14 \| 1.016 \| DISEASES 23234 \| DNAJC9 \| 3.042 \| DISEASES 29102 \| DROSHA \| 1.969 \| DISEASES 1855 \| DVL1 \| 1.223 \| DISEASES 1915 \| EEF1A1 \| 1.099 \| DISEASES 83481 \| EPPK1 \| 2.552 \| DISEASES 2195 \| FAT1 \| 1.001 \| DISEASES 2263 \| FGFR2 \| 1.516 \| DISEASES 2272 \| FHIT \| 2.138 \| DISEASES 2805 \| GOT1 \| 1.698 \| DISEASES 3068 \| HDGF \| 1.445 \| DISEASES 3123 \| HLA-DRB1 \| 2.107 \| DISEASES 8519 \| IFITM1 \| 1.377 \| DISEASES 3594 \| IL12RB1 \| 1.164 \| DISEASES 83737 \| ITCH \| 1.733 \| DISEASES 3655 \| ITGA6 \| 1.917 \| DISEASES 3710 \| ITPR3 \| 1.253 \| DISEASES 3745 \| KCNB1 \| 1.282 \| DISEASES 81033 \| KCNH6 \| 2.269 \| DISEASES 10112 \| KIF20A \| 2.056 \| DISEASES 688 \| KLF5 \| 1.142 \| DISEASES 113730 \| KLHDC7B \| 3.622 \| DISEASES 5650 \| KLK7 \| 1.098 \| DISEASES 3880 \| KRT19 \| 1.935 \| DISEASES 3855 \| KRT7 \| 1.743 \| DISEASES 3914 \| LAMB3 \| 2.158 \| DISEASES 3965 \| LGALS9 \| 1.153 \| DISEASES 3981 \| LIG4 \| 1.369 \| DISEASES 348120 \| LINC01193 \| 1.734 \| DISEASES 121227 \| LRIG3 \| 2.381 \| DISEASES 23542 \| MAPK8IP2 \| 3.263 \| DISEASES 10747 \| MASP2 \| 1.307 \| DISEASES 4149 \| MAX \| 1.848 \| DISEASES 27030 \| MLH3 \| 1.568 \| DISEASES 64710 \| NUCKS1 \| 2.255 \| DISEASES 11240 \| PADI2 \| 1.385 \| DISEASES 5094 \| PCBP2 \| 1.867 \| DISEASES 10401 \| PIAS3 \| 1.447 \| DISEASES 5580 \| PRKCD \| 1.648 \| DISEASES 5696 \| PSMB8 \| 1.049 \| DISEASES 5743 \| PTGS2 \| 1.238 \| DISEASES 22827 \| PUF60 \| 2.154 \| DISEASES 83871 \| RAB34 \| 2.002 \| DISEASES 5890 \| RAD51B \| 1.389 \| DISEASES 5893 \| RAD52 \| 1.298 \| DISEASES 2889 \| RAPGEF1 \| 1.172 \| DISEASES 5915 \| RARB \| 1.661 \| DISEASES 11186 \| RASSF1 \| 1.627 \| DISEASES 51634 \| RBMX2 \| 3.281 \| DISEASES 5996 \| RGS1 \| 1.495 \| DISEASES 54101 \| RIPK4 \| 2.075 \| DISEASES 6239 \| RREB1 \| 1.68 \| DISEASES 57142 \| RTN4 \| 1.227 \| DISEASES 6304 \| SATB1 \| 1.232 \| DISEASES 286205 \| SCAI \| 1.445 \| DISEASES 6318 \| SERPINB4 \| 2.435 \| DISEASES 23451 \| SF3B1 \| 2.112 \| DISEASES 6424 \| SFRP4 \| 2.041 \| DISEASES 6477 \| SIAH1 \| 1.375 \| DISEASES 9058 \| SLC13A2 \| 2.047 \| DISEASES 284111 \| SLC13A5 \| 2.053 \| DISEASES 6622 \| SNCA \| 1.292 \| DISEASES 6657 \| SOX2 \| 2.098 \| DISEASES 6696 \| SPP1 \| 1.387 \| DISEASES 10388 \| SYCP2 \| 2.938 \| DISEASES 23345 \| SYNE1 \| 1.301 \| DISEASES 161176 \| SYNE3 \| 3.154 \| DISEASES 8407 \| TAGLN2 \| 3.243 \| DISEASES 6892 \| TAPBP \| 1.171 \| DISEASES 6942 \| TCF20 \| 1.569 \| DISEASES 84260 \| TCHP \| 1.027 \| DISEASES 7012 \| TERC \| 1.002 \| DISEASES 200424 \| TET3 \| 1.828 \| DISEASES 56649 \| TMPRSS4 \| 1.546 \| DISEASES 5987 \| TRIM27 \| 1.9 \| DISEASES 7204 \| TRIO \| 2.062 \| DISEASES 55503 \| TRPV6 \| 1.168 \| DISEASES 117581 \| TWIST2 \| 1.319 \| DISEASES 10537 \| UBD \| 1.499 \| DISEASES 7422 \| VEGFA \| 1.3 \| DISEASES 6935 \| ZEB1 \| 1.178 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1090
Disease	cervical squamous cell carcinoma
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:8) HP:0002860 \| Squamous cell carcinoma \| 73 HP:0002664 \| Neoplasia \| 2 HP:0000125 \| Pelvic kidney \| 1 HP:0012531 \| Pain \| 1 HP:0002840 \| Lymphadenitis \| 1 HP:0002835 \| Aspiration \| 1 HP:0005584 \| Renal cell carcinoma \| 1 HP:0001903 \| Anemia \| 1

Disease ID	1090
Disease	cervical squamous cell carcinoma
Manually Symptom	UMLS \| Name(Total Manually Symptoms:6) C2364133 \| infection C0950124 \| papillomavirus infection C0850639 \| premalignant lesion C0036527 \| ovarian metastasis C0022572 \| keratoacanthomas C0011633 \| dermatomyositis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0009450 \| infection \| 2

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:8)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs2229546	23280621	3587	IL10RA	umls:C0279671	BeFree	Cervical SCC risk was associated with the minor alleles of the IL10RA rs9610 3' UTR SNP (OR=1.76, 95% CI=1.15-2.68) and two synonymous IL12RB2 SNPs (rs4297265, OR=0.46, 95% CI=0.26-0.82; rs2229546, OR=0.43, 95% CI=0.21-0.87).	0.000271442	2013	IL12RB2	1	67395837	C	A,G,T
rs3087386	18470628	51455	REV1	umls:C0279671	BeFree	Compared with the REV1 Phe257Ser, women carrying Ser257Ser and Phe257Ser genotypes had a significantly decreased the risk for cervical carcinoma or cervical squamous cell carcinoma.	0.000271442	2008	REV1	2	99439044	A	G
rs3181224	23280621	3593	IL12B	umls:C0279671	BeFree	Finally, the minor allele of the IL12B rs3181224 3' UTR SNP was associated with a reduced risk of vulvar SCC (OR=0.30, 95% CI=0.12-0.74).	0.000271442	2013	LOC105377683	5	159313842	A	G
rs4297265	23280621	3587	IL10RA	umls:C0279671	BeFree	Cervical SCC risk was associated with the minor alleles of the IL10RA rs9610 3' UTR SNP (OR=1.76, 95% CI=1.15-2.68) and two synonymous IL12RB2 SNPs (rs4297265, OR=0.46, 95% CI=0.26-0.82; rs2229546, OR=0.43, 95% CI=0.21-0.87).	0.000271442	2013	NA	NA	NA	NA	NA
rs4705343	26252302	3845	KRAS	umls:C0279671	BeFree	These findings indicate that miR-143/145 rs4705343 and KRAS rs712 may contribute to the etiology of CSCC in Chinese women.	0.000542884	2015	MIR143;MIR143HG	5	149428518	T	C
rs712	26252302	3845	KRAS	umls:C0279671	BeFree	These findings indicate that miR-143/145 rs4705343 and KRAS rs712 may contribute to the etiology of CSCC in Chinese women.	0.000542884	2015	KRAS	12	25209618	A	C
rs9298814	12490311	3451	IFNA17	umls:C0279671	BeFree	The distribution of IFNA17 Ile184Arg genotype among SCCA cases (Ile/Ile, 21%; Arg/Ile, 57%; and Arg/Arg, 22%) was different significantly from that among NCC (Ile/Ile, 32%; Arg/Ile, 56%; and Arg/Arg, 12%) (P=0.0345).	0.000271442	2003	IFNA17	9	21227623	A	G,C
rs9610	23280621	3587	IL10RA	umls:C0279671	BeFree	Cervical SCC risk was associated with the minor alleles of the IL10RA rs9610 3' UTR SNP (OR=1.76, 95% CI=1.15-2.68) and two synonymous IL12RB2 SNPs (rs4297265, OR=0.46, 95% CI=0.26-0.82; rs2229546, OR=0.43, 95% CI=0.21-0.87).	0.000271442	2013	IL10RA	11	118001371	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1090
Disease	cervical squamous cell carcinoma
Case	(Waiting for update.)

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